thrombin time การใช้

• Normal values for thrombin time are 12 to 14 seconds.
• Prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen tests should be performed.
• Thrombin time can be prolonged by heparin, fibrin degradation products, and fibrinogen deficiency or abnormality.
• The thrombin time compares the rate of clot formation to that of a sample of normal pooled plasma.
• Performing a thrombin time on the test plasma can provide useful additional information for the interpretation of mixing tests.
• Studies in animals and in vitro studies have demonstrated that protamine neutralizes the antithrombin activity of LMWHs, normalizing the aPTT and thrombin time.
• In both haemophilia A and B, there is spontaneous bleeding but a normal bleeding time, normal prothrombin time, normal thrombin time, but prolonged partial thromboplastin time.
• Other tests performed in any patient with bleeding problems are a complete blood count ( especially platelet counts ), activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen level.
• The classical coagulation tests such as PT ( prothrombin time ), aPTT ( activated partial thromboplastin time ) or thrombin time are not very sensitive for hyperfibrinolysis, and influenced by numerous other variables.
• Unlike thrombin, reptilase is resistant to inhibition by antithrombin III . Thus, the reptilase time is not prolonged in blood samples containing heparin, hirudin, or direct thrombin inhibitors, whereas the thrombin time will be prolonged in these samples.